Vanderbilt's game with Ole Miss will take on an NFL atmosphere in 2015.
The Commodores home game against the Rebels on Sept. 6 will be played at LP Field, which is the home of the NFL's Tennessee Titans.
"With eight home games, we thought moving this one off campus will further create an electric, bowl-like atmosphere," Vanderbilt athletic director David Williams said in a press release.
Vanderbilt has played four times at LP Field and is 2-2, with wins in the Music City Bowl in 2008 and 2012 plus losses to Tennessee in 2000 and 2002.
Ole Miss beat Georgia Tech in last year's Music City Bowl.